Clinical and epidemiologic features of SARS-CoV-2 in dogs and cats compiled through national surveillance in the United States

OBJECTIVE: To characterize clinical and epidemiologic features of SARS-CoV-2 in companion animals detected through both passive and active surveillance in the US. ANIMALS: 204 companion animals (109 cats, 95 dogs) across 33 states with confirmed SARS-CoV-2 infections between March 2020 and December 2021. PROCEDURES: Public health officials, animal health officials, and academic researchers investigating zoonotic SARS-CoV-2 transmission events reported clinical, laboratory, and epidemiologic information through a standardized One Health surveillance process developed by the CDC and partners. RESULTS: Among dogs and cats identified through passive surveillance, 94% (n = 87) had reported exposure to a person with COVlD-19 before infection. Clinical signs of illness were present in 74% of pets identified through passive surveillance and 27% of pets identified through active surveillance. Duration of illness in pets averaged 15 days in cats and 12 days in dogs. The average time between human and pet onset of illness was 10 days. Viral nucleic acid was first detected at 3 days after exposure in both cats and dogs. Antibodies were detected starting 5 days after exposure, and titers were highest at 9 days in cats and 14 days in dogs. CLINICAL RELEVANCE: Results of the present study supported that cats and dogs primarily become infected with SARS-CoV-2 following expo- sure to a person with COVID-19, most often their owners. Case investigation and surveillance that include both people and animals are necessary to understand transmission dynamics and viral evolution of zoonotic diseases like SARS-CoV-2.

The animal keeping culture and the motivation of animal keepers in Hungary

Background: In the past few decades the animal keeping culture and habits have changed a lot internationally, some animals have become family members. The COVID-19 pandemic has created an unprecedented situation in the world, including Hungary. In many places, the quarantine period was associated with Isolation and, therefore, an increase in the number of companion animals. Objectives: Our aims were to (1) survey the animal keeping culture and habits, (2) examine the motivation of the owners and (3) explore the attitudes about adoption, neutering, breeding and the use of livestock animals in Hungary. Materials and Methods: Specialized surveys were conducted among 843 persons through social media and personal interviews from 20 June to 30 August 2021 by using a questionnaire including 16 questions. The chosen groups were compared with Fisher's Exact test and Chi-square test. Results and Discussion: 97.0% of the respondents regard their dog as a family member. Nearly 25% of the respondents do not wish to neuter their dogs, because they want to breed the dogs or they find it unnecessary. The primary reason for cat keepers not to neuter their pet is the financial issue. Animal keepers and women are significantly more likely to consider their animal as a family member (p < 0.001). Men, the elderly, people who live in the countryside and those who have only elementary education think that neutering is of less importance (p < 0.001). Non-animal keepers, elderly people and men think more negatively about adoption. Buying an animal from a breeder is more important to the younger age groups (p < 0.001) arid those who live in Budapest (p < 0.01). 42.3% of the respondents gave the lowest evaluation scores to the assessment of the livestock units. Women, people from younger age groups (p < 0.05) and those who have higher education (p < 0.001) think more negatively about the use of farm animals. Non-animal keepers, the elderly and people of lower education consider the livestock animals' emotional intelligence lower (p < 0.05). Men (p < 0.001), people over 65 years of age (p < 0.001) and of lower education (p < 0:01), and also non-animal keepers (p < 0.001) accept significantly easier the use of livestock animals.

Warm-blooded animal toxoplasmosis and its connection to COVID-19: a review

Toxoplasmosis is a zoonotic illness that spreads from animals to people. Toxoplasma gondii, a protozoan parasite that infects warm-blooded mammals, causes the sickness. Toxoplasmosis is a parasitic infection that causes abortion and death in animals. Cats are the parasite's sole sexual hosts, thus they're the only ones who can get it. Because cats are frequent pets, they are highly likely to come into touch with humans. As a result, the disease poses a risk to human health. The potential danger is influenced by the frequency of oocyst secretion and the level of contamination in the environment. Toxoplasmosis has serious consequences for both animal and human health, hence preventative actions should be taken to reduce the dangers. COVID-19 is affected by such methods as well. Toxoplasmosis is thought to increase immunological and immunosuppressive factors, which increases the chance of SARS-CoV-2 infection and the severity of the resulting COVID-19. Research into Toxoplasma gondii intermediate hosts might help understand COVID-19's dynamics and determine if the virus can be transferred from animals to humans. We explore what we know about Toxoplasma gondii infection as a human parasitosis and how it may alter the course of SARS-CoV-2 infection in this review study.

Incidence and sero-surveillance of feline viruses in Korean cats residing in Gyeonggi-do

Incidences of major feline viral diseases provide basic information for preventing viral disease in cats. Despite the growing interest in feline viral diseases, sero-surveillances have been lacking. In this study, we analyzed the diagnoses of feline viral diseases and conducted a sero surveillance of feline panleukopenia virus (FPV), feline calicivirus (FCV), feline herpesvirus-1 (FHV-1), and feline infectious peritonitis virus (FIPV) in Korean cats. Of the 204 confirmed cases since 2015, the numbers of diagnoses for FPV, FIPV, FCV, feline influenza virus, and FHV-1 were 156, 32, 12, 3, and 1 case, respectively. In total, 200 sera, collected between 2019 and 2021, were screened for the presence of antibodies against FPV, 2 FCVs, FHV-1, and FIPV using a hemagglutination inhibition test and a virus-neutralizing assay (VNA). The overall seropositive rates in cats tested for FPV, the 2 FCVs, FHV-1, and FIPV were 92.5%. 42.0%, 37.0%, 52.0%, and 14.0%, respectively. A low correlation (r = 0.466) was detected between the VNA titers of 2 FCV strains. The highest incidence and seropositive rate of FPV reveal that FPV is circulating in Korean cats. The low r-value between 2 FCVs suggests that a new feline vaccine containing the 2 kinds of FCVs is required.

Shared Spaces, Shared Suffering: Exploring the Effects of COVID-19 on Urban Animal Advocacy Organizations in Chicago and Kansas City, USA

COVID-19‘s impact on the daily lives of millions of urban residents around the world has been significant, yet next to many humans are companion animals who have shared the "lockdown” experience. Much as the pandemic has upended human socio-economic lives, the pandemic has also upended companion animal lives, as well as the organizations working to help them in urban areas. This chapter, grounded in the perspective of animal geography, explores the positive and negative effects of COVID-19 on three U.S. animal advocacy organizations: two in Chicago, Illinois and one in Kansas City, Missouri. From early lockdown closures that temporarily stopped all direct care and outreach services, to a post-lockdown recognition of the increasing need for economic support to help families care for their companion animals, to the time lost managing feral populations, we show that the impact of COVID-19 cannot be seen as purely a human phenomenon, but must be seen as a more-than-human experience with long-term ramifications for human-animal relations in urban areas and beyond. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Coinfection in the cases of feline panleukopenia: a literature review

Coinfection caused by bacteria, parasites, or viruses complicates almost all feline panleukopenia virus (FPV) infections. Pathogens that colonize the gastrointestinal tract, Clostridium perfingens, Clostridium piliforme, Cryptosporidium spp, Giardia spp, Tritrichomonas fetus, canine parvovirus type 2,Salmonella sp., feline coronavirus, feline bocavirus, and feline astrovirus were isolated in the presence of FPV infection. Complex mechanisms between viruses, bacteria, protozoa, and hosts contribute to the pathogenesis and severity of coinfection. Prompt and accurate diagnosis, vaccination precautions, and appropriate treatment play important roles in reducing morbidity and mortality. This article outlines the etiology, pathogenesis, diagnosis, prevention, and treatment that can help veterinarians and pet owners improve their knowledge of managing the diseases.

When support is "pawsed": Increased attachment mediates the association between loss of support and pet bereavement during the pandemic

The COVID-19 pandemic has introduced and exacerbated innumerable stressors for Americans. Pet ownership has been shown to help individuals cope with stress and loneliness. However, given the shorter life spans of most pets compared to humans, many pet owners inevitably dealt with pet loss and its associated grief during the pandemic. We surveyed 284 community and college participants that had suffered the loss of a pet during the pandemic. We asked these pet owners about their pandemic-related experiences over the preceding year with regard to the types of losses they experienced, whether they experienced isolation through quarantine and their perception of social support. We also measured their general attachment to pets along with the grief they felt as a result of pet loss. We hypothesized that greater loss, increased isolation, and reduced social support would lead to increased attachment to pets, which would intensify the experience of grief. Mediated regression analyses revealed a direct effect of loss on grief that was not mediated through attachment. Unexpectedly, greater perceived social support showed an indirect effect on grief through stronger attachment to pets. Results confirm prior findings that greater pet attachment leads to more intense pet grief, but the attachment was not intensified through loss of support social or increased isolation as predicted. It is important to recognize the substantial impact of pet loss, especially during stressful times, and this topic deserves further investigation, perhaps with a greater focus on the type of pet and pet-specific measures of attachment. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Restrospective study of hemogram profile in effusive feline infectious peritonitis

Feline Infectious Peritonitis (FIP) is highly mortality disease in cats. The reliable and fast diagnosis is crucial to the best prognosis. The aim of this study to evaluate the hemogram profile in cats infected with effusive FIP. Twenty cats had been diagnosed effusive FIP at Animal Clinic Department of Internal Medicine, Faculty Veterinary Medicine, Universitas Gadjah Mada were used in the study. The diagnosis were based on clinical examination, ultrasound, x-ray, rivalta test, and rapid test. The hemogram profile were analyzed include routine hematology and serum biochemistry. Hemogram profile in effusive FIP showed the decreased hematocrit, hyperproteinemia, and leukocytosis with an average 22.9+or-7.4%;9.0+or-2.2 g/dL;22425+or-4116 cells/mm3 respectively. Erythrocyte, hemoglobin and fibrinogen levels were still in the normal range. The results of differential leukocytes revealed that 90% cats had neutrophilia and 75% lymphopenia with an average 20066+or-3337 cells/mm3 and 1861+or-1818 cells/mm3 respectively. The blood chemistry profile showed 60% of cats experienced increase in SGPT and SGOT with an average 138.4+or-72.3 IU/L and 101+or-60.5 IU/L respectively. Hyperglobulinemia was found in 90% samples with an average 6.7+or-0.8 g/dL. All cats have a low albumin:globulin ratio with an average 0.3+or-0.1. The hemogram profile of effusive FIP were: leukocytosis, neutrophilia, lymphopenia, hyperglobulinemia, and decreased albumin-globulin ratio..

Development of broadly reactive antibody therapeutics for SARS-CoV-2

Various antibody therapeutics has been developed for the treatment and suppression of the 2019 outbreak of novel coronavirus（SARS-CoV-2）infection. A major limitation in the development of SARS-CoV-2 neutralizing antibodies is the occurrence and spread of escape variants that have mutations in the spike glycoprotein. The coronaviruses are carried by various wild animals, domestic animals, and pets, and there have been cases of Severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus transmission from animals to people, resulting in a large spread of infection in people. There is also a possibility that cross-species transmission of SARS-CoV-2 may occur in the future. Considering these factors, the development of antibody therapeutics with broad cross-reactivity against SARS-CoV-2 variants and other coronaviruses is required.Alternate :抄録2019年に発生した新型コロナウイルス（SARS-CoV-2）感染症の治療や発症抑制のためにさまざまな抗体医薬の開発が進められている。SARS-CoV-2中和抗体の開発で大きな障壁となるのが、スパイク糖タンパク質に変異をもつ変異株の発生と感染拡大である。またコロナウイルスは多くの野生動物や家畜、愛玩動物が保有しており、これまでにも重篤呼吸器症候群コロナウイルスや中東呼吸器症候群コロナウイルスが動物からヒトへ伝播して大きく感染が広がったケースがある。SARS-CoV-2についても動物が起源であると考えられており、今後も種を越えた伝播が発生する可能性が考えられる。これらを踏まえて、SARS-CoV-2変異株や類縁コロナウイルスに対する交差反応性に優れた抗体医薬の開発が求められる。

Overcoming the social stigma of losing a pet: Considerations for counseling professionals

During the COVID-19 pandemic, individuals found themselves spending more time with their pets and relied on them to maintain normalcy and provide security during isolation. Pets play a significant role in the lives of their caregivers, taking on different attachment roles depending on the needs of the individual. Grieving the death of a pet continues to be disenfranchised in society. Perceptions of judgment can lead individuals to grieve the loss without social support. The present review builds on research in the field of pet loss and human bereavement and factors in the impact of the COVID-19 pandemic on human-animal attachment A goal of the present review is to provide counselors with perspectives to consider in their practice when working with clients who have attachments to their companion animals and to acknowledge the therapeutic benefits of working through the grief process to resolution as a way to continue the bond with a deceased pet. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Focus on laryngeal disease in the cat

This is a title only record which contains no .

Infectious disease Roundup 2022

This paper describes the epidemiology, prevalence, transmission, prevention and control of some infectious diseases in companion animals, livestock, wild animals and humans in Ontario, Canada, in 2022, including SARS-CoV-2;Echinococcus multilocularis, Leishmania spp. and SARS-CoV-2;antimicrobial stewardship resources;2 cases of rabid dogs imported from Iran (July 2021 and January 2022);prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriacea, Dirofilaria immitis, Brucella canis, canine parainfluenza and adeno- and herpes viruses in dogs recently imported from Asia;Paragonimus kellicotti lung flukes and Streptococcus equi subsp. zooepidemicus in dogs;African swine fever in pet pigs, backyard pigs and wild pigs and blastomycosis in dogs and humans.

Disputes between neighbors in Mexican cities during the COVID‐19 pandemic

We estimate the effect of the COVID‐19 pandemic lockdown on disputes between neighbors using a panel of 70 cities from across Mexico and a difference‐in‐difference strategy. Our results show that the lockdown exacerbated disputes related to pets as nuisances by 45%, noise by 31%, unruly children by 23%, and garbage by 22%. We do not find any effect of the COVID‐19 lockdown on disputes related to gossip. We also estimate heterogeneous effects of the alcohol sales ban across Mexican municipalities. Our findings suggest that this public policy helped to reduce the likelihood of disputes related to noise and garbage.Alternate :Se estimó el efecto del confinamiento de la pandemia COVID‐19 en las disputas entre vecinos utilizando un panel de 70 ciudades de todo México y una estrategia de diferencias en diferencias. Los resultados muestran que el confinamiento exacerbó las disputas relacionadas con las mascotas como molestias en un 45%, el ruido en un 31%, los niños revoltosos en un 23% y la basura en un 22%. No se encontró ningún efecto del confinamiento de COVID‐19 en las disputas relacionadas con el chismorreo. También se estimaron los efectos heterogéneos de la prohibición de la venta de alcohol en los municipios mexicanos. Los resultados sugieren que esta política pública contribuyó a reducir la probabilidad de conflictos relacionados con el ruido y la basura.Alternate :抄録COVID‐19のパンデミックによるロックダウンが近隣住民間の口論に及ぼす影響を、メキシコ全国の70都市のパネルデータと差分の差分法を用いて推定した。結果から、ロックダウンによって口論が以下のように増加したことが示された。ペットによる迷惑:45%、騒音:31%、素行不良の子供:23%、ゴミ:22%。ゴシップに関する口論には、COVID‐19のロックダウンの影響は見られなかった。また、我々は、メキシコの地方自治体におけるアルコール販売禁止による不均一な影響も推定した。調査結果から、アルコール販売の禁止が騒音とゴミに関する口論の可能性を減らすのに役立ったことが示唆された。

Could Molnupiravir Have an Ameliorative Effect in Pets with COVID-19?

Since the last months of 2019, SARS-CoV-2, commonly referred to as COVID-19, has impacted the global economy and health care industries. Previous studies on SARS-CoV-2 have shown that it can also affect household pets. Coronaviruses have long been associated with pets, and prophylaxis is provided through vaccination programs. Today, although the levels of those requiring intensive care and death rates are decreasing through the extensive vaccination program initiated for humans, there is still no effective treatment for humans or pets. SARS-CoV-2 can spread and infect animals through similar mechanisms to that of humans. Like other types of coronavirus, Feline Infectious Peritonitis (FIP)-like multi-organ failure can develop in pets with COVID-19. Until now, supportive treatment has been performed to prevent severe cases and improve the quality of life. Molnupiravir, approved for emergency use by the FDA, is a prodrug of ribonucleoside analog with a low incidence of adverse side effects. Studies have shown that Molnupiravir has a preservative effect by preventing SARS-CoV-2 viral replication. Therefore we propose that Molnupiravir may also be used as a protective agent for pets and thus prevent multiple organ failures. © 2022 by the authors.

Whole-Genome Characterization of SARS-CoV-2 Reveals Simultaneous Circulation of Three Variants and a Putative Recombination (20B/20H) in Pets, Brazzaville, Republic of the Congo.

Following the emergence of SARS-CoV-2, cases of pets infected with variants circulating among humans were reported. In order to evaluate the occurrence of SARS-CoV-2 circulation among pets in the Republic of the Congo, we conducted a ten-month study of dogs and cats living in COVID-19-positive households in Brazzaville and neighboring localities. Real-time PCR and the Luminex platform were used to detect SARS-CoV-2 RNA and antibodies to SARS-CoV-2 RBD and S proteins, respectively. Our results show for the first time the simultaneous circulation of several variants of SARS-CoV-2, including viruses from clades 20A and 20H and a putative recombinant variant between viruses from clades 20B and 20H. We found a high seroprevalence of 38.6%, with 14% of tested pets positive for SARS-CoV-2 RNA. Thirty-four percent of infected pets developed mild clinical signs, including respiratory and digestive signs, and shed the virus for about one day to two weeks. These results highlight the potential risk of SARS-CoV-2 interspecies transmission and the benefits of a "One Health" approach that includes SARS-CoV-2 diagnosis and surveillance of viral diversity in pets. This approach aims to prevent transmission to surrounding wildlife as well as spillback to humans.

The love of pets in managing remote work challenges during Covid-19.

In response to the Covid-19 pandemic, a large number of employed individuals all over the world were obliged to work remotely during lockdown. This article focuses on the coping mechanisms which individuals used to manage this difficult situation, specifically the impact which loving and caring for pets had on the way in which people dealt with the challenges of the remote-working environment. Methodologically, this qualitative study used a phenomenological research design to understand the lived experience of the participants in the study. Ten qualitative semi-structured interviews were conducted with pet owners during the Covid-19 lockdown period in South Africa. The sample was recruited using purposeful and snowball sampling techniques. Data were analysed through content analysis while qualitative quality criteria were applied. Findings show pets supported their owners in many different ways during the pandemic and only the animal's presence supported the owners at home physically, psychologically and emotionally. They helped to reduce the stress of their owners and create a homely atmosphere. Pets played a specific role in providing love, companionship, strong emotional and affective bonds and by creating experiences of comfort, positive as well as negative distraction from work, and physical presence. The experience of love was one major aspect of the relationships between pets and humans. Conclusions are drawn and recommendations are given with regard to future research, highlighting how organisations and consultants can use the positive influences of pets in remote-working scenarios.

Pet ownership and lifestyle behaviours of immunosuppressed individuals and their relatives in the context of COVID-19 pandemic.

The COVID-19 pandemic and containment measures will likely have a detrimental impact on immunosuppressed individuals' lifestyle behaviours. Increasing evidence suggests that pet ownership is positively associated with healthier lifestyle. Yet, no study has investigated the potential benefits of pet ownership on lifestyle behaviours of immunosuppressed individuals, a population at increased risk of COVID-19 complications. This study aims to examine 1) changes in light, moderate and vigorous intensity physical activity (LPA, MPA, VPA), sedentary time (SED), and sleep duration, assessed by comparing "before COVID-19 pandemic" and "past 7 days" (i.e., current, during pandemic) self-reported behaviours in immunosuppressed individuals and their relatives; 2) to assess if changes in lifestyle behaviours are associated with pet ownership status and whether age is a moderator of these associations. A convenience sample of 132 participants (65.2% female, 41.3% ≥55 years of age) provided self-reported LPA, MPA, VPA (days/week), SED and sleep (min/day) and pet ownership status using an online questionnaire (May-August 2020). Descriptive analyses, paired T-tests, Cohen's d effect size and linear regressions were conducted. Results show that participants reported a decrease in VPA (-0.56 days/week, d = 0.34; p < 0.01) and an increase in SED (106.79 min/day, d = -0.81; p < 0.01). Stratified analysis revealed that having at least one dog, compared to not owning pets, is associated with a reduced decline in LPA, MPA and VPA and an increase in sleep in participants aged < 55 years old only. Having a dog appears to be positively associated with healthy lifestyle behaviours in younger and middle age immunosuppressed individuals.

SARS-CoV-2 Seroprevalence Studies in Pets, Spain.

SARS-CoV-2 can infect domestic animals such as cats and dogs. The zoonotic origin of the disease requires surveillance on animals. Seroprevalence studies are useful tools for detecting previous exposure because the short period of virus shedding in animals makes detection of the virus difficult. We report on an extensive serosurvey on pets in Spain that covered 23 months. We included animals with exposure to SARS-CoV-2-infected persons, random animals, and stray animals in the study. We also evaluated epidemiologic variables such as human accumulated incidence and spatial location. We detected neutralizing antibodies in 3.59% of animals and showed a correlation between COVID-19 incidence in humans and positivity to antibody detection in pets. This study shows that more pets were infected with SARS-CoV-2 than in previous reports based on molecular research, and the findings highlight the need to establish preventive measures to avoid reverse zoonosis events.

Infection of SARS-CoV-2 in domestic dogs associated with owner viral load.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pet owners are reported to be a risk factor for infection of their pets; however, the influence of the viral load and associated risks has not been fully established. This study aimed to assess potential association of viral load in owners with the presence of SARS-CoV-2 infection in their dogs. Of 20 SARS-CoV-2-positive pet owners from 13 families in Curitiba, Brazil, 5 of 22 (22.7%) dogs were positive for SARS-CoV-2. Viral presence was detected in oropharyngeal samples for 2 of 5 (40.0%) dogs at 8 and 9 days after the first positive sample. Detection of SARS-CoV-2 in these dogs was associated with higher viral loads in the owners and close owner contact. All 5 RT-qPCR-positive dogs had antibodies to at least one viral protein tested in the serological assay. Molecular detection of SARS-CoV-2 in dogs was statistically associated with clinical signs in owners such as cold, cough, or diarrhea (P = 0.039), number of positive persons in the household (P = 0.002), and higher viral load (P = 0.039). Such findings serve as a warning for risks of human to dog infection, mainly due to sharing beds and other close interactions without protection. In conclusion, people with coronavirus disease 2019 (COVID-19), particularly in households with multiple residents and high viral load, should take the same preventive measures when interacting with their dogs during self-isolation as they do with people.

Development of the pet owner connectedness scale (POCS)

Studies that have reported on the loneliness protective effect of pet ownership have recently been called into question owing to methodological drawbacks, including the use of inappropriate scales of measurement for loneliness in pet owner samples. It has also been recently demonstrated that pet interactions may only influence positive, not negative, human affect. In light of these recent advances, the current study aimed to create a new scale focusing on the inverse experience of loneliness: connectedness. An initial 24-item scale was developed using qualitative data collected from our previous study investigating the impact of pet ownership for Australians living alone during a government-enforced lockdown in response to COVID-19. Study 1 included 934 dog and cat owners who self-selected into the online study. Factor analyses revealed two distinct factors, and only items that loaded uniquely on one factor were retained. Study 2 included 526 dog and cat owners who self-selected into the online study, which confirmed the two-factor structure and established validity and reliability of the scale. The result was a 14-item Pet Owner Connectedness Scale (POCS) with two subscales: (i) owner-pet connection, and (ii) connectedness through pet. Hence, we present evidence for a new scale that can be used to measure the positive social states of connectedness that owners may gain from their pets. This may provide a good alternative to more traditional methods such as measuring the buffering effect pets have on negative social states such as loneliness. It may also offer a more robust method to measure the impact of pet interactions on their owners. (PsycInfo Database Record (c) 2022 APA, all rights reserved)